Biochemical characterization of terbinafine-resistantTrichophytonrubrumisolates
نویسندگان
چکیده
منابع مشابه
Biochemical characterization of terbinafine-resistant Trichophyton rubrum isolates.
We investigated the biochemical basis for resistance in six sequential clinical isolates of Trichophyton rubrum, from the same patient, which exhibited high-level primary resistance to terbinafine. Cellular ergosterol biosynthesis was measured by incorporation of [14C]acetate, and microsomal squalene epoxidase was assayed by conversion of [3H]squalene to squalene epoxide and lanosterol. Direct ...
متن کاملBiological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
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The article entitled “Aplastic Anemia Associated with Oral Terbinafine: A Case Report and Review of the Literature”, written by Kantarcıoğlu et al. and published in a recent issue of your journal, was quite interesting [1]. Here we would like to emphasize some relevant points. In the assessment of 425 cases by van der Klauw et al., the most common causes of drug-related agranulocytosis or neutr...
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ژورنال
عنوان ژورنال: Medical Mycology
سال: 2004
ISSN: 1369-3786,1460-2709
DOI: 10.1080/13693780410001661482